1. SV Zulte Waregem (BEL) v Newcastle United FC (ENG)
2. SC Braga (POR) v Parma FC (ITA)
3. RC Lens (FRA) v Panathinaikos FC (GRE)
4. Bayer 04 Leverkusen (GER) v Blackburn Rovers FC (ENG)
5. Hapoel Tel-Aviv FC (ISR) v Rangers FC (SCO)
6. AS Livorno Calcio (ITA) v RCD Espanyol (ESP)
7. Feyenoord (NED) v Tottenham Hotspur FC (ENG)
8. Fenerbahçe SK (TUR) v AZ Alkmaar (NED)
9. Werder Bremen (GER) v AFC Ajax (NED)
10. FC Spartak Moskva (RUS) v RC Celta de Vigo (ESP)
11. PFC CSKA Moskva (RUS) v Maccabi Haifa FC (ISR)
12. AEK Athens FC (GRE) v Paris Saint-Germain FC (FRA)
13. SL Benfica (POR) v FC Dinamo 1948 Bucuresti (ROU)
14. FC Steaua Bucuresti (ROU) v Sevilla FC (ESP)
15. FC Shakhtar Donetsk (UKR) v AS Nancy-Lorraine (FRA)
16. FC Girondins de Bordeaux (FRA) v CA Osasuna (ESP)
1st-leg matches: 14/15 February
2nd-leg matches: 22 February
Round of 16
Winners of Match 1 v Winners of Match 8
Winners of Match 11 v Winners of Match 6
Winners of Match 5 v Winners of Match 16
Winners of Match 2 v Winners of Match 7
Winners of Match 14 v Winners of Match 15
Winners of Match 3 v Winners of Match 4
Winners of Match 12 v Winners of Match 13
Winners of Match 10 v Winners of Match 9